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The Science behind Moonai

Approved by +30,000 women

What if we could combine the proven approach of mindfulness apps with the science of sound to alter pain perception? And what if we could at the same time investigate on women's pain, stress perception and changes through hormonal fluctuations (menstrual phase, pregnancy, fertility treatment, ...)?

From April 1st, to January 1st, 2026, There was a 46.74% net reduction in pain levels across users based on their pain score from10 (maximum) to 0 (no pain).

Users with high pain levels such as Pain score 8 (severe) and Pain score 9 (unbearable) saw significant reductions of 25.49% and 18.18%, respectively.
Users reporting no pain (Pain 0) increased by 22.26%.

74.3% of our users reported an overall wellbeing improvement.

See how our neuroscience-based sounds and our educational content can help you feel better

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Sound reduces pain, but not all sounds counts

Brain scans show that your brain perceives music, pain and emotions in a similar way. Listening to pleasing music increases activity in parts of the brain’s reward center, and some studies suggest that music can interfere with the signals your brain interprets as pain.

An example with menstrual pain:

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Certain sounds, frequencies and rhythms can impact the central nervous system and help reduce the perception of menstrual pain.

But not all sounds count, which is why we are partnering with neuroscientists, gynecologists, and psychoacoustic experts to provide the most effective sounds for period pain relief.

Some say their period pain is similar to what contractions during labor feel like. Others describe their cramps as if someone was stabbing, piercing, or scratching their insides. Research* has proven that music significantly minimizes that pain.

*Effect of Music on Labor Pain Relief, Anxiety Level and Postpartum Analgesic Requirement: A Randomized Controlled Clinical Trial. S. Simavli and I. Gumus and I. Kaygusuz and M. Yildirim and B. Usluogullari and H. Kafalı. Gynecologic and Obstetric Investigation, 2014, vol. 78, pp. 244 – 250.

Pain prediction affects perception

Your pain has physiological causes, like inflammation or medical conditions. But research shows there are other factors that also increase how much pain you feel: your thoughts, your emotions, and your social support. This means that you can, literally, amplify or minimize how much pain you feel each month.

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Our past experiences often shape our expectations of the future, which in turn can influence how we perceive future events.

Previous work* has shown that our expectation of how painful a stimulus will be can influence our perception of that stimulus and our response to it.

*Prediction of pain outcomes in a randomized controlled trial of dose–response of spinal manipulation for the care of chronic low back pain. Darcy Vavrek, Mitchell Haas, Moni Blazej Neradilek, and Nayak Polissar. BMC Musculoskelet Disord. 2015; 16: 205.

Untreated pelvic and period pain has consequences

Period and pelvic pain increases oxidative stress and changes the brain structure of those who experience it. Research also shows that type of pain increases pain sensitivity, changes bone density, alters HPA axis, and is a general risk factor for temporomandibular disorders and chronic pain.

All these are reasons why your pain should be addressed and ended, now.

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Our Experts

Supported since day one by award-winning and world-leading pioneers in reproductive health, pelvic pain management, neuroscience, and neurological music, #slay.

Moonai is proud to collaborate with expert individuals in these fields and work with renowned institutions such as Harvard Medical School, the University of Toronto, the University of Western Australia, Barcelona Health Hub, and Pompeu Fabra University.

Dr. Juan Sebastian Martin-Saavedra
Clinical Researcher and Expert in Music for Primary Dysmenorrhea (see here).

PhD Alan Harvey
Advisor in Music, Neuroscience, and Neurophysiology, renowned for his work on "Oxytocins & Music." (see his Ted Talk)

Dr. Maria ULOKO
Urologist revolutionising the field of comprehensive sexual health. (see her website here)

Dr. Lee Bartel
Neuroscience and Sound Supervision, known for his work on "Music as Medicine" and its effects at the cellular level (see his Ted Talk)

Tom Middleton
Sound Engineering and Functional Music Advisor, certified coach in Spatial and Sleep Music, and award-winning music producer and DJ.

Adam Hewett
AI-Music and Technology Advisor, Neuro-engineer, CEO of Evoked Response, and inventor of the neurotech utilized by Brain.fm.

FAQs

Everything you need to know about our app and how it can help you feel better on the daily.

general

What is Moonai?

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Moonai is the first research-driven app dedicated to transforming how we manage and understand women’s health, specifically targeting pelvic and period pain. BOOM! We have diligently developed an on-the-go digital solution designed to reduce physical pain and stress while enhancing mental clarity. By combining neuroscience, sound therapy, and Cognitive Behavioral Therapy (CBT), we offer immediate support at your fingertips.While you listen, we investigate. Moonai captures the real-world evidence needed to study how pain affects individuals throughout their unique health journeys—from menstrual cycles and fertility treatments to menopause. Together, we are refining the science of sound to drive faster clinical discovery, better treatments, and a clearer path to diagnosis.

How does it work (summary)?

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How it works: Science in motionMoonai utilizes the neuroscientific concept of brainwave entrainment—a process where specific sound and visual stimuli influence brainwave activity to help modulate mood, pain perception, and cognitive focus. By adjusting parameters such as frequencies, beats per minute (BPM), and harmonic structures, we create soundscapes designed to influence your physiological and psychological response.No "Magic Frequencies," Just Active Investigation.We don't believe in a one-size-fits-all miracle sound. Instead, we use proven scientific principles as our starting point to investigate what works best for each individual. Every time you listen and track your symptoms, you help us validate which interventions are most effective, for whom, and when. We continuously input these real-world findings back into the app, refining our sounds to drive personalized relief and support clinical discovery.

When do people use Moonai?

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C'est une excellente base car elle montre la traction réelle (+30K !) et l'évolution organique de l'app. Voici une version plus structurée et percutante pour votre FAQ, qui met en avant votre approche data-driven et l'aspect investigation :Why do people use Moonai?

With over 30,000 users and counting, Moonai has evolved into a versatile support tool. Currently, 70% of our community reports feeling better after a session. While we initially launched to tackle menstrual pain and PMS, our data-driven approach allowed us to grow alongside our users.By analyzing real-world patterns, we’ve expanded to support a wide range of reproductive health challenges—including IVF, egg freezing, pregnancy, and menopause.

Our community uses Moonai for:
70% for Sleep & Pain Relief: Navigating physical discomfort and hormonal insomnia.
30% for Mental Clarity: Enhancing focus and managing brain fog.

Daily Resilience: From managing migraines to emotional regulation and stress relief in high-pressure moments.Because we are constantly investigating the data, we don’t just offer sounds; we optimize the entire experience based on how pain and stress actually affect your daily life. Whether it’s clinical support or simply needing a moment to breathe and reset, Moonai adapts to your specific journey.

Why is there a Premium version? Why can it not only be free?

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Moonai is not an NGO. We are developing a complex solution that requires substantial time, expertise, and resources. Supporting a new user has direct costs—from secure servers for your data to the continuous scientific investigation we perform.Every subscription supports our team’s dedicated work. To make Moonai sustainable while keeping it accessible, we use a hybrid model:
Premium Subscriptions: Directly funding the tools, newsletters, and improvements based on your feedback.
Strategic Monetization: We utilize ad monetization and anonymized data licensing to fuel our research and keep the app running.
Think of it this way: you wouldn't expect a pharmacy to provide medicine for free. By choosing Premium, you aren't just paying for an app; you are investing in a future where women's pain is finally visible, studied, and treated.

I am a man, can I use Moonai?

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The hormonal police won’t stop you—so yes, go for it. Think of Moonai like a painkiller: it doesn’t need to know exactly where the pain is to influence the brain regions that control it. Whether you are a man, someone without a cycle, or part of the "testosterone squad," you can use Moonai and experience the benefits of our soundscapes.

However, here is what we are investigating:Our research, our data engine, and our neuroscience protocols are strictly optimized for the female hormonal profile.

Scientific evidence shows that pain perception and stress management are influenced by sex differences and hormonal variations.
Because women’s health has been historically neglected, we have chosen to stand our ground and focus our investigation here. While anyone can listen, we are dedicated to solving the specific biological and psychological complexities of women's reproductive health to finally bridge the gender data gap.

the science

What neuroscience?

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Neuroscience-based and Cognitive Behavioral Therapy (CBT) approach is combined with ambient-drone soundscapes carefully designed by our handpicked team of music producers and scientists. We take pride in being the original O.G., creating these soundscapes with love.

Is there a difference in pain perception between men and women?

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Studies have shown that pain perception does differ based on the sex.

In short: Yes. While social conditioning and psychosocial factors play a significant role, numerous laboratory studies show that biological mechanisms create distinct differences in how we perceive and tolerate pain.

The most critical factor for us? Hormones. Sex hormones directly influence pain sensitivity; for many, both pain thresholds and tolerance fluctuate significantly throughout the stages of the menstrual cycle. This is exactly what we are investigating: how to map these biological shifts to provide better support.

But fear not, sweet summer child. We’re just scratching the surface here. We’ll be diving deeper into the "why" and "how" with more in-depth educational content in our Learn section.T
here are elements such as social conditioning and psychosocial factors, but many laboratory studies of humans have described sex differences in sensitivity to noxious stimuli, which suggests that biological mechanisms underlie such differences. In addition, sex hormones influence pain sensitivity; pain threshold and pain tolerance in women vary with the stage of the menstrual cycle. But fear not, sweet summer child, we will have some more educational content on the topic in the learn section.
(source 1, 2, 3, and 4)

Do pain prediction affect perception?

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Absolutely. Your pain is real, but your brain is not a passive receiver—it’s a prediction machine.While period pain has clear physiological causes, such as inflammation or underlying medical conditions, research shows that thoughts, emotions, and social support act like a volume knob. You can literally amplify or minimize the intensity of the pain you experience based on how your brain "prepares" for it.

Our past experiences shape our expectations. If your brain expects a stimulus to be agonizing, it can heighten your neurological response before the pain even peaks. This is where Moonai’s combination of CBT and soundscapes comes in: by shifting your brain’s expectations and emotional state, we help you rewrite the "prediction," ultimately altering the intensity of the perception itself.

sound

How do sounds and music impact me? Decoding Sound: Beyond the Frequency

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At Moonai, we start with a fundamental truth: Not all sounds and music have the same effect. Certain frequencies and rhythms can directly impact the central nervous system to help downregulate pain signals. This is why we partner with neuroscientists, gynecologists, and psychoacoustic experts to deliver the most effective sounds for stress and pain relief.However, we believe "functional sound" is more than just a melody. It is a complex puzzle that Moonai is uniquely positioned to solve.

Mapping the Variables of the Future
While we currently build on validated foundations, our research is evolving to capture and define the specific variables that make sound truly "medical grade." We are building the infrastructure to investigate:

a. The Spatial Dimension: Investigating the impact of Stereo vs. Surround vs. fully immersive Spatial Audio.

b. The Delivery Method: Tracking the difference between the mental isolation of headphones and the physical, vibrational response of speakers.

c. The Listening State: Analyzing whether a sound is more effective when active (guided CBT/intentional) or passive (ambient background).

d. Acoustic Architecture: Defining how duration, timbre, and melodic complexity interact with your individual hormonal phase.

Our Evolutionary Mission
We aren't just giving you a sound; we are investigating the "Why." By capturing more nuanced data, Moonai is moving toward a future where we can provide a personalized "audio recipe"—knowing exactly which sound architecture and variables will be most effective for your pain on any given day of your cycle.We are turning a subjective experience into a validated evidence base for the next generation of sound-based medicine.

How can I know more about the artists producing the sounds and visuals?

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We will offer soon the possibility to know more about the artists through the app and through your preference. You can check in "About Us" the different artists with who we work and their links. Show them some love.

What are "soundscapes"?

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A soundscape is an acoustic environment—a combination of sounds that forms a specific atmosphere. While the term was popularized by R. Murray Schafer to describe the mix of nature (biophony), earth (geophony), and human life (anthropophony), Moonai views soundscapes as functional frameworks.

Think of it as a dedicated "audio space" tailored for your nervous system. Rather than a traditional song with a linear melody, a Moonai soundscape is a structured layers of:

- Textures: Ambient layers designed to reduce cognitive load.
- Frequencies: Specifically chosen to influence brainwave activity (entrainment).
- Rhythms: Subtle pulses that help regulate internal states like breathing or heart rate.

Why we use them for pain
Unlike music designed for entertainment, a Moonai soundscape is built to be "functional." By creating a consistent and predictable acoustic field, we help the brain shift its focus away from "scanning" for pain signals.
It provides a stable background that helps the nervous system transition from a state of "high alert" (pain/stress) to a state of rest and recovery.
We are currently investigating how different architectures—from standard stereo to more complex spatial arrangements—affect this transition differently.

What are “isochronic tones”?

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So, isochronic tones are repetitive audio pulses (like a "Vuuu-v' Vuuu'v" noise) that are evenly spaced, producing a distinct and consistent rhythm (imagine placing your hands on your ears and pressing them, then releasing them; it's like that, but better, and you don't look stupid).

These tones are used for various purposes such as relaxation, meditation, and enhancing focus. They were first introduced as a sound therapy technique in the mid-20th century and have since gained popularity for their potential benefits in promoting mental and emotional well-being.

What are "binaural beats"?

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Binaural beats are essentially an auditory illusion. Here’s the trick: we play two slightly different frequencies in each ear (for example, 200 Hz in the left and 210 Hz in the right). Your brain’s reaction? It basically says, "Wait, this doesn’t add up," and compensates for the discrepancy by "creating" a third, phantom tone—the beat.This concept has been around since the 19th century, and while popular culture treats it like a digital drug, we prefer to stay grounded.

The Scientist's Reality Check:
- Not Magic:
Despite the internet's obsession with "healing frequencies," binaural beats aren't a miracle cure. They are a tool for potential brainwave influence, not a magic switch for the brain.
- Headphones Mandatory: Unlike isochronic tones, if you aren't wearing headphones, the "illusion" doesn't happen. Your brain won't create the third tone, and you’re just listening to two slightly out-of-tune hums.

The Big "Maybe": While many report benefits for relaxation or focus, clinical evidence is still a mixed bag. It’s not a lack of evidence, but a lack of consistency.
Most existing studies fail because the methodology is too broad.

Our Investigation: This is exactly why Moonai exists. We aren't just "playing beats"; we are investigating the actual efficacy of these illusions. We want to understand if—and how—they truly impact pain perception and stress, or if the benefit comes from the ritual of listening itself. We use what has shown promise, but we remain the lead investigators in validating their role in women’s health.

Do all sounds help reduce the pain?

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The short answer is no. For a sound to be truly "functional," it must do more than just be pleasant.

Brain scans reveal that your brain processes music, pain, and emotions in overlapping regions. While "pleasing" music can activate your reward center, only specific rhythms, frequencies, and acoustic textures have the precision required to downregulate the central nervous system and interfere with pain signals.

Beyond "Magic" – A Scientific InvestigationWe don't believe in miracle frequencies. Whether your pain feels like labor-like contractions or a sharp, piercing sensation, we know that the right auditory intervention can significantly minimize that perception—but only if the methodology is precise.This is why we partner with neuroscientists, gynecologists, and psychoacoustic experts.

We are moving beyond the "maybe" of current studies by investigating the variables that most researchers ignore:

- The "When": How your hormonal phase (follicular vs. luteal) changes how your brain processes sound.
- The "How": The exact impact of isochronic tones versus binaural beats, and the difference between stereo and spatial audio architectures.
- The "Who": How your unique biological profile influences your response to specific soundscapes.

Turning Data into a Diagnosis
Moonai was born from my own journey with a genetic condition. I realized that to get a diagnosis and treatment, we need more than just relief—we need evidence.

By using Moonai, you aren’t just listening; you are leading your own investigation. We are capturing the missing data to turn scientific "maybes" into a personalized "audio recipe," finally bridging the gender data gap and helping you navigate your medical journey with clarity and power.

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Help us improve the app

We have a clear plan on the new features, fixes and improvements we want to make. However, we know that our vision is not everything and we might be missing something.

This is why we created a feedback form for you to be able to submit your thoughts, ask for updates and just share with us how you would improve Moonai to keep helping women every day.

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Join our Moonai family and improve your wellbeing, mental health, focus and sleep patterns today with our app. Let it become your go-to, natural way of managing your pain and stress.

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